The methylene chloride solution is then dried over anhydrous magnesium sulfate, filtered and the solvent removed under vacuum.
The solvent is then removed under vacuum to obtain 2-cyclopropylcarbonylamido-5chlorobenzophenone as a residue which is dissolved in 1 liter of methylene chloride, washed twice with 5% hydrochloric acid, and then twice with 10% potassium hydroxide.
The reaction is refluxed 2? hours and allowed to cool to room temperature. To 400.5 g (1.73 mols) of 2-amino-5-chlorobenzophenone dissolved in 220 g (2.18 mols) of triethylamine and 3.5 liters of tetrahydrofuran is added cautiously 181 g (1.73 mols) of cyclopropanecarboxylicacid chloride.
Manufacturing Process: Preparation of 2-Cyclopropylcarbonylamido-5-Chlorobenzophenone:
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